Gou-Teng

Uncaria rhynchophylla, commonly known as Gou-Teng or Chotoko, holds a significant place in traditional Chinese and Japanese medicine, particularly valued for its antiepileptic properties and its role as a major component in the formulation 'Yokukansan,' used to treat agitation in the elderly. This herb exhibits neuroprotective, anticonvulsive, and antipsychotic properties akin to Aripiprazole, a pharmaceutical drug. Known for its application in treating hypertension, convulsive disorders, headaches, and dizziness, Uncaria rhynchophylla contains various alkaloid structures, notably Rhynchophylline and the potent GME (Geissoschizine methyl ether). While research involving oral ingestion of the herb or isolated alkaloids is primarily in the animal phase, promising findings suggest GME's antipsychotic properties on serotonin and dopamine receptors, contributing to anxiety reduction and mitigating social aggression. Additionally, Gou-Teng exhibits neuroprotective effects by preventing the activation of glial cells in response to inflammation, highlighting its potential anti-epileptic properties. Although further investigation is needed, there is also potential for Gou-Teng to lower blood pressure through the activation of nitric oxide signaling.