Common Names: Hydroxy-MethylButyrate, HMB-FA, beta-hydroxy-beta-methylbutyrate, HMB-Ca, β-hydroxy β-methylbutyrate, CaHMB, β-Hydroxy β-methylbutyric acid
Scientific Names: 3-hydroxy-3-methylbutanoic acid
HMB (Hydroxymethylbutyrate) is a metabolite of the essential amino acid leucine, known for its role in preventing muscle protein breakdown and reducing the loss of fat-free mass. While it may help preserve strength and muscle mass in older adults during catabolic states, such as aging or illness, evidence of benefits for athletes is inconclusive. HMB stimulates muscle protein synthesis and shows effectiveness in preventing exercise-associated muscle damage after high-intensity workouts. Derived from leucine, HMB is naturally produced in the body and found in small amounts in grapefruit, alfalfa, and catfish. Widely used as a dietary supplement in the fitness and bodybuilding communities, HMB is believed to promote muscle growth, reduce muscle breakdown, and aid in muscle tissue repair. Athletes and those engaged in resistance training often turn to HMB supplements to enhance workout results and support muscle recovery. While generally considered safe, individuals with specific fitness goals should consult with healthcare professionals for personalized advice on dosage and usage.