Spermidine

Spermidine, a significant polyamine compound, has a pivotal role in various metabolic processes in organisms. Originally discovered in semen, this aliphatic polyamine is present in ribosomes and living tissues. Its synthesis is catalyzed by spermidine synthase (SPDS) from putrescine, making it a precursor to other polyamines like spermine. Spermidine is integral in synchronizing a host of biological processes, including maintaining membrane potential and regulating intracellular pH and volume. It influences Ca2+ influx through the N-methyl-D-aspartate (NMDA) receptor, associated with the nitric oxide synthase (NOS) and the cGMP/PKG pathway, affecting Na+, K+-ATPase activity in the cerebral cortex.

Notably, spermidine is recognized for its potential as a longevity agent in mammals, primarily due to its role in promoting autophagy, a cellular maintenance mechanism. It may act through the MAPK pathway by inhibiting Raf phosphorylation or by affecting cytosolic autophagy-related protein acetylation. Beyond autophagy, spermidine contributes to reducing inflammation, regulating lipid metabolism, and controlling cell growth, proliferation, and death. As levels of spermidine decrease with age, correlating with age-related diseases, dietary intake of spermidine-rich foods like soybeans, chicken liver, green peas, corn, shellfish, and blue cheese is encouraged. Spermidine is found in particularly high quantities in soybeans, wheat germ, cheese, and ground beef. Spermidine's efficacy in lifespan extension, observed across various species, further underscores its potential in maintaining cellular health and mitigating age-related health declines.

The appropriate dosage of Spermidine in milligrams (mg) can vary depending on the specific product and individual health goals. Typically, Spermidine supplements are available in capsules or powder form, with common doses ranging from 250 mg to 1,000 mg per day. However, the optimal dosage may depend on factors such as age, overall health, and the purpose for which it is being used. To ensure safe and effective use, it's crucial to follow the manufacturer's recommended dosage instructions on the product label and consult with a healthcare professional for personalized guidance, particularly when using Spermidine for specific health or longevity-related goals. Professional advice can help determine the most suitable and safe dose for your individual needs.